Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model (2024)

Papadopoulos, M. A., Papadopulos, N. A., Jannowitz, C., Boettcher, P., Henke, J., Stolla, R., Zeilhofer, H. F., Kovacs, L. (2005). Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model. Fetal Diagnosis and Therapy, 21(1), 105-114. https://doi.org/10.1159/000089059

Papadopoulos, Moschos A. ; Papadopulos, Nikolaos A. ; Jannowitz, Christina et al. / Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model. In: Fetal Diagnosis and Therapy. 2005 ; Vol. 21, No. 1. pp. 105-114.

@article{a135c67bcf044cd68fcf4587a15fe095,

title = "Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model",

abstract = "Objective: To evaluate maxillary growth following in utero repair of surgically created cleft lip and alveolar (CLA)-like defects by means of three-dimensional (3D) computer tomographic (CT) cephalometric analysis in the mid-gestational sheep model. Methods: In 12 sheep fetuses a unilateral CLA-like defect was created in utero (untreated control group: 4 fetuses). Four different bone grafts were used for the alveolar defect closure. After euthanasia, CT scans of the skulls of the fetuses, 3D reconstructions, and a 3D-CT cephalometric analysis were performed. Results: The comparisons between the operated and nonoperated skull sides as well as of the maxillary asymmetry among the experimental groups revealed no statistically significant differences of the 12 variables used. Conclusions: None of the surgical approaches used for the in utero correction of CLA-like defects seem to affect significantly postsurgical maxillary growth; however, when bone graft healing takes place, a tendency for almost normal maxillary growth can be observed.",

keywords = "Cleft lip and palate, Fetal bone graft, Intrauterine surgery, Maxillary growth, Mid-gestational sheep model, Three-dimensional cephalometric analysis, Three-dimensional computed tomography",

author = "Papadopoulos, {Moschos A.} and Papadopulos, {Nikolaos A.} and Christina Jannowitz and Peter Boettcher and Julia Henke and Rudolf Stolla and Zeilhofer, {Hans Florian} and Laszlo Kovacs and Edgar Biemer",

year = "2005",

month = dec,

doi = "10.1159/000089059",

language = "English",

volume = "21",

pages = "105--114",

journal = "Fetal Diagnosis and Therapy",

issn = "1015-3837",

publisher = "S. Karger AG",

number = "1",

}

Papadopoulos, MA, Papadopulos, NA, Jannowitz, C, Boettcher, P, Henke, J, Stolla, R, Zeilhofer, HF, Kovacs, L 2005, 'Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model', Fetal Diagnosis and Therapy, vol. 21, no. 1, pp. 105-114. https://doi.org/10.1159/000089059

Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model. / Papadopoulos, Moschos A.; Papadopulos, Nikolaos A.; Jannowitz, Christina et al.
In: Fetal Diagnosis and Therapy, Vol. 21, No. 1, 12.2005, p. 105-114.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model

AU - Papadopoulos, Moschos A.

AU - Papadopulos, Nikolaos A.

AU - Jannowitz, Christina

AU - Boettcher, Peter

AU - Henke, Julia

AU - Stolla, Rudolf

AU - Zeilhofer, Hans Florian

AU - Kovacs, Laszlo

AU - Biemer, Edgar

PY - 2005/12

Y1 - 2005/12

N2 - Objective: To evaluate maxillary growth following in utero repair of surgically created cleft lip and alveolar (CLA)-like defects by means of three-dimensional (3D) computer tomographic (CT) cephalometric analysis in the mid-gestational sheep model. Methods: In 12 sheep fetuses a unilateral CLA-like defect was created in utero (untreated control group: 4 fetuses). Four different bone grafts were used for the alveolar defect closure. After euthanasia, CT scans of the skulls of the fetuses, 3D reconstructions, and a 3D-CT cephalometric analysis were performed. Results: The comparisons between the operated and nonoperated skull sides as well as of the maxillary asymmetry among the experimental groups revealed no statistically significant differences of the 12 variables used. Conclusions: None of the surgical approaches used for the in utero correction of CLA-like defects seem to affect significantly postsurgical maxillary growth; however, when bone graft healing takes place, a tendency for almost normal maxillary growth can be observed.

AB - Objective: To evaluate maxillary growth following in utero repair of surgically created cleft lip and alveolar (CLA)-like defects by means of three-dimensional (3D) computer tomographic (CT) cephalometric analysis in the mid-gestational sheep model. Methods: In 12 sheep fetuses a unilateral CLA-like defect was created in utero (untreated control group: 4 fetuses). Four different bone grafts were used for the alveolar defect closure. After euthanasia, CT scans of the skulls of the fetuses, 3D reconstructions, and a 3D-CT cephalometric analysis were performed. Results: The comparisons between the operated and nonoperated skull sides as well as of the maxillary asymmetry among the experimental groups revealed no statistically significant differences of the 12 variables used. Conclusions: None of the surgical approaches used for the in utero correction of CLA-like defects seem to affect significantly postsurgical maxillary growth; however, when bone graft healing takes place, a tendency for almost normal maxillary growth can be observed.

KW - Cleft lip and palate

KW - Fetal bone graft

KW - Intrauterine surgery

KW - Maxillary growth

KW - Mid-gestational sheep model

KW - Three-dimensional cephalometric analysis

KW - Three-dimensional computed tomography

UR - http://www.scopus.com/inward/record.url?scp=29144449873&partnerID=8YFLogxK

U2 - 10.1159/000089059

DO - 10.1159/000089059

M3 - Article

C2 - 16354987

AN - SCOPUS:29144449873

SN - 1015-3837

VL - 21

SP - 105

EP - 114

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

IS - 1

ER -

Papadopoulos MA, Papadopulos NA, Jannowitz C, Boettcher P, Henke J, Stolla R et al. Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model. Fetal Diagnosis and Therapy. 2005 Dec;21(1):105-114. doi: 10.1159/000089059